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In outpatient health care settings like physicians’ offices, there are significant risks to patients’ safety, including delays in diagnosis and treatment which result in disease progression, preventable complications of treatment, and adverse drug events. Few systems exist to recognize and ameliorate such patient safety problems, and the overall aim is to design, develop, test, and evaluate innovative solutions to improve patient safety.

Main findings:

  • Implementation science is a valuable approach to respond to the constraints of a health care environment. We began our investigation asking ourselves, “how can the co-design of health information technology interventions influence uptake?” However, we found that the unique context of health care delivery plays a major role in uptake, and other implementation outcomes, across settings serving diverse patients. We learned that workflow analysis and journey mapping with front line staff can help reduce implementation challenges and improve the sustainability of an intervention.

  • There is limited epidemiological data on the extent of safety gaps, particularly in safety-net settings that struggle with fragmented record keeping systems. We sought to address ambulatory safety issues, such as delayed and missed monitoring of sub-critical test results. Many of the concerns that clinicians said kept them up at night - such as incomplete follow-up of incidental pulmonary nodules - lack data describing the extent of the problem. Therefore, we needed to invest in studying the epidemiology behind these safety gaps to better understand the impact of delayed and missed monitoring on patient outcomes.  

Publications

  1. Cedars B, Lisker S, Borno HT, Kamal P, Breyer B, Sarkar U. An electronic registry to improve adherence to active surveillance monitoring among men with prostate cancer at a safety-net hospital: protocol for a pilot study. Pilot Feasibility Stud. 2019 Aug 14;5:101. doi: 10.1186/s40814-019-0482-x. PMID: 31428442; PMCID: PMC6694525.

  2. Lyson HC, Sharma AE, Cherian R, Patterson ES, McDonald KM, Lee SY, Sarkar U. A Qualitative Analysis of Outpatient Medication Use in Community Settings: Observed Safety Vulnerabilities and Recommendations for Improved Patient Safety. J Patient Saf. 2021 Jun 1;17(4):e335-e342. doi: 10.1097/PTS.0000000000000590. PMID: 30882615; PMCID: PMC7060148.

  3. Lyles CR, Tieu L, Sarkar U, Kiyoi S, Sadasivaiah S, Hoskote M, Ratanawongsa N, Schillinger D. A Randomized Trial to Train Vulnerable Primary Care Patients to Use a Patient Portal. J Am Board Fam Med. 2019 Mar-Apr;32(2):248-258. doi: 10.3122/jabfm.2019.02.180263. PMID: 30850461; PMCID: PMC6647853.

  4. Sadasivaiah S, Lyles CR, Kiyoi S, Wong P, Ratanawongsa N. Disparities in Patient-Reported Interest in Web-Based Patient Portals: Survey at an Urban Academic Safety-Net Hospital. J Med Internet Res. 2019 Mar 26;21(3):e11421. doi: 10.2196/11421. PMID: 30912747; PMCID: PMC6454341.

  5. Khoong EC, Cherian R, Matta GY, Lyles CR, Schillinger D, Ratanawongsa N. Perspectives of English, Chinese, and Spanish-Speaking Safety-Net Patients on Clinician Computer Use: Qualitative Analysis. J Med Internet Res. 2019 May 22;21(5):e13131. doi: 10.2196/13131. PMID: 31120020; PMCID: PMC6549473.

  6. Schmajuk G, Jafri K, Evans M, Shiboski S, Gianfrancesco M, Izadi Z, Patterson SL, Aggarwal I, Sarkar U, Dudley RA, Yazdany J. Pneumocystis jirovecii pneumonia (PJP) prophylaxis patterns among patients with rheumatic diseases receiving high-risk immunosuppressant drugs. Semin Arthritis Rheum. 2019 Jun;48(6):1087-1092. doi: 10.1016/j.semarthrit.2018.10.018. Epub 2018 Nov 3. PMID: 30449650; PMCID: PMC6499720.

  7. Gupta K, Lisker S, Rivadeneira NA, Mangurian C, Linos E, Sarkar U. Decisions and repercussions of second victim experiences for mothers in medicine (SAVE DR MoM). BMJ Qual Saf. 2019 Jul;28(7):564-573. doi: 10.1136/bmjqs-2018-008372. Epub 2019 Feb 4. PMID: 30718333; PMCID: PMC7173705.

  8. Fontil V, Radcliffe K, Lyson HC, Ratanawongsa N, Lyles C, Tuot D, Yuen K, Sarkar U. Testing and improving the acceptability of a web-based platform for collective intelligence to improve diagnostic accuracy in primary care clinics. JAMIA Open. 2019 Feb 1;2(1):40-48. doi: 10.1093/jamiaopen/ooy058. PMID: 31984344; PMCID: PMC6952011.

  9. Matta GY, Khoong EC, Lyles CR, Schillinger D, Ratanawongsa N. Finding Meaning in Medication Reconciliation Using Electronic Health Records: Qualitative Analysis in Safety Net Primary and Specialty Care. JMIR Med Inform. 2018 May 7;6(2):e10167. doi: 10.2196/10167. PMID: 29735477; PMCID: PMC5962827.

  10. Ratanawongsa N, Quan J, Handley MA, Sarkar U, Schillinger D. Language-concordant automated telephone queries to assess medication adherence in a diverse population: a cross-sectional analysis of convergent validity with pharmacy claims. BMC Health Serv Res. 2018 Apr 6;18(1):254. doi: 10.1186/s12913-018-3071-4. PMID: 29625571; PMCID: PMC5889590.

  11. Giardina TD, Haskell H, Menon S, Hallisy J, Southwick FS, Sarkar U, Royse KE, Singh H. Learning From Patients' Experiences Related To Diagnostic Errors Is Essential For Progress In Patient Safety. Health Aff (Millwood). 2018 Nov;37(11):1821-1827. doi: 10.1377/hlthaff.2018.0698. PMID: 30395513; PMCID: PMC8103734.

  12. Schmajuk G, Tonner C, Trupin L, Li J, Sarkar U, Ludwig D, Shiboski S, Sirota M, Dudley RA, Murray S, Yazdany J. Using health-system-wide data to understand hepatitis B virus prophylaxis and reactivation outcomes in patients receiving rituximab. Medicine (Baltimore). 2017 Mar;96(13):e6528. doi: 10.1097/MD.0000000000006528. PMID: 28353614; PMCID: PMC5380298.

  13. Ratanawongsa N, Matta GY, Bohsali FB, Chisolm MS. Reducing Misses and Near Misses Related to Multitasking on the Electronic Health Record: Observational Study and Qualitative Analysis. JMIR Hum Factors. 2018 Feb 6;5(1):e4. doi: 10.2196/humanfactors.9371. PMID: 29410388; PMCID: PMC5820457.

  14. McDonald KM, Su G, Lisker S, Patterson ES, Sarkar U. Implementation science for ambulatory care safety: a novel method to develop context-sensitive interventions to reduce quality gaps in monitoring high-risk patients. Implement Sci. 2017 Jun 24;12(1):79. doi: 10.1186/s13012-017-0609-5. PMID: 28646886; PMCID: PMC5483297.

  15. Luxenberg A, Chan B, Khanna R, Sarkar U. Efficiency and Interpretability of Text Paging Communication for Medical Inpatients: A Mixed-Methods Analysis. JAMA Intern Med. 2017 Aug 1;177(8):1218-1220. doi: 10.1001/jamainternmed.2017.2133. PMID: 28628695; PMCID: PMC5818786.

  16. Ratanawongsa N, Matta GY, Lyles CR, Koenig CJ, Barton JL, Yu K, Schillinger D. Multitasking and Silent Electronic Health Record Use in Ambulatory Visits. JAMA Intern Med. 2017 Sep 1;177(9):1382-1385. doi: 10.1001/jamainternmed.2017.2668. PMID: 28672379; PMCID: PMC5585046.

  17. Sarkar U, Lyles C, Steinman M, Huang ES, Moffet HH, Whitmer RA, Warton EM, Karter AJ. Changes in Medication Use After Dementia Diagnosis in an Observational Cohort of Individuals with Diabetes Mellitus. J Am Geriatr Soc. 2017 Jan;65(1):77-82. doi: 10.1111/jgs.14429. Epub 2016 Sep 19. PMID: 27642180; PMCID: PMC5366252.

  18. Issaka RB, Singh MH, Oshima SM, Laleau VJ, Rachocki CD, Chen EH, Day LW, Sarkar U, Somsouk M. Inadequate Utilization of Diagnostic Colonoscopy Following Abnormal FIT Results in an Integrated Safety-Net System. Am J Gastroenterol. 2017 Feb;112(2):375-382. doi: 10.1038/ajg.2016.555. Epub 2016 Dec 13. PMID: 28154400; PMCID: PMC6597438.

  19. Ratanawongsa N, Chan LL, Fouts MM, Murphy EJ. The Challenges of Electronic Health Records and Diabetes Electronic Prescribing: Implications for Safety Net Care for Diverse Populations. J Diabetes Res. 2017;2017:8983237. doi: 10.1155/2017/8983237. Epub 2017 Jan 18. PMID: 28197420; PMCID: PMC5286474.

  20. Lee SY, Cherian R, Ly I, Horton C, Salley AL, Sarkar U. Designing and Implementing an Electronic Patient Registry to Improve Warfarin Monitoring in the Ambulatory Setting. Jt Comm J Qual Patient Saf. 2017 Jul;43(7):353-360. doi: 10.1016/j.jcjq.2017.03.006. Epub 2017 Apr 20. PMID: 28648221; PMCID: PMC5489234.

  21. Clarity C, Sarkar U, Lee J, Handley MA, Goldman LE. Clinician Perspectives on the Management of Abnormal Subcritical Tests in an Urban Academic Safety-Net Health Care System. Jt Comm J Qual Patient Saf. 2017 Oct;43(10):517-523. doi: 10.1016/j.jcjq.2017.05.007. Epub 2017 Sep 6. PMID: 28942776; PMCID: PMC7757427.

  22. Lowry C, Orr K, Embry B, Nguyen M, Petersen A, James C, Seidel K, Ratanawongsa N. Primary care scribes: writing a new story for safety net clinics. BMJ Open Qual. 2017 Oct 25;6(2):e000124. doi: 10.1136/bmjoq-2017-000124. PMID: 29435506; PMCID: PMC5699154.

  23. Patterson ES, Militello LG, Su G, Sarkar U. Characterizing a Naturalistic Decision Making Phenomenon: Loss of System Resilience Associated with Implementation of New Technology. J Cogn Eng Decis Mak. 2016 Sep;10(3):229-243. doi: 10.1177/1555343416652524. Epub 2016 Jun 15. PMID: 28138316; PMCID: PMC5271605.

  24. Mirsky JB, Tieu L, Lyles C, Sarkar U. Readability assessment of patient-provider electronic messages in a primary care setting. J Am Med Inform Assoc. 2016 Jan;23(1):202-6. doi: 10.1093/jamia/ocv087. Epub 2015 Jul 15. PMID: 26177659; PMCID: PMC7814916.

  25. Mirsky JB, Tieu L, Lyles C, Sarkar U. A Mixed-Methods Study of Patient-Provider E-Mail Content in a Safety-Net Setting. J Health Commun. 2016;21(1):85-91. doi: 10.1080/10810730.2015.1033118. Epub 2015 Sep 2. PMID: 26332306; PMCID: PMC5431571.

  26. Giardina TD, Sarkar U, Gourley G, Modi V, Meyer AN, Singh H. Online public reactions to frequency of diagnostic errors in US outpatient care. Diagnosis (Berl). 2016 Mar;3(1):17-22. doi: 10.1515/dx-2015-0022. Epub 2016 Feb 19. PMID: 27347474; PMCID: PMC4917213.

  27. Lyles C, Schillinger D, Sarkar U. Connecting the Dots: Health Information Technology Expansion and Health Disparities. PLoS Med. 2015 Jul 14;12(7):e1001852. doi: 10.1371/journal.pmed.1001852. PMID: 26172977; PMCID: PMC4501812.

  28. Lyles CR, Sarkar U. Health literacy, vulnerable patients, and health information technology use: where do we go from here? J Gen Intern Med. 2015 Mar;30(3):271-2. doi: 10.1007/s11606-014-3166-5. PMID: 25588688; PMCID: PMC4351277.